Chastity and orgasm denial discussion

My keyholder is beginning to discuss keeping me locked around the clock for extended stretches, and I am quite keen on that idea. Still, I want to ask those with more experience what health advice they have regarding long-term wear. Is it best to set it and forget it unless there is persistent ache in my penis or testicles (aside from the standard pain of morning erections)? Some mornings I’ve requested an unlock due to erection discomfort, but I’m getting better at pushing through them—standing up, walking about, and urinating without taking off the cage. This hasn’t caused lasting hurt, yet it leaves me slightly unsure if that’s a good approach.